CCP4i: Graphical User Interface
	MIR Tutorial Bath

ISOMORPHOUS REPLACEMENT and ANOMALOUS SCATTERING

This tutorial is distributed by CCP4 in postscript form as $CDOC/Iso_repl_itickle_tut.bath.ps. The HTML version is more recent (1998) and comes with the following disclaimer:

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The copyright tutorial material supplied may be freely reproduced without further formality, subject to the following conditions:

1. Copies are made only for educational purposes within the user's own institution.
2. No payment is made for printed copies of the material, except to cover reasonable printing costs.
3. Material mounted in electronic form on a document server is rendered inaccessible from outside the confines of the user's institution, except by express permission of the copyright owner.
4. A copy of this notice accompanies any material, in part or in whole, mounted on a server.
5. The source of the material is acknowledged in any course documentation that refers to it.
6. No warranty is implied as to the fitness of the material for any purpose whatsoever.

Ian J. Tickle, Birkbeck College, University of London, UK. Copyright 1996.

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Section 1. Strategy

Section 2. Scaling

Section 3. Patterson search for heavy-atom sites

Section 4. MIRAS case study - Porphobilinogen deaminase

Section 5. Phase determination by multiple isomorphous replacement

Section 6. Refinement of heavy-atom parameters

Section 7. Suggested procedure for phased refinement with MLPHARE

Section 8. Suggested procedure for phasing and refinement with MLPHARE/VECREF

Section 9. Statistics of phasing

Section 10. Multiwavelength anomalous diffraction (MAD)

Section 11. Further reading